The assembly of nucleosomes and higher‐order chromatin structures has been extensively studied in vitro. Provided that non‐specific charge interactions are controlled, all the information for correct assembly is found to be inherent in the macromolecular components. Cellular extracts which can assemble chromatin in vitro with nucleosomes correctly spaced on the DNA have been studied in detail and also used to investigate the role of chromatin structure in transcription. However, the mechanisms of chromatin assembly in vivo are still controversial.

This long-awaited work by prominent Harvard psychologist Stephen Kosslyn integrates a twenty-year research program on the nature of high-level vision and mental ...

It is widely recognized that lives and activities can be meaningful or meaningless, but few have appreciated that they can also be anti-meaningful. Anti-meaning is the polar opposite of meaning. Our purpose in this essay is to examine the nature and importance of this new and unfamiliar topic. In the first part, we sketch four theories of anti-meaning that correspond to leading theories of meaning. In the second part, we argue that anti-meaning has significance not only for our attempts to (...) theorize about meaning in life, but also for our ability to lead meaningful lives in the modern world. (shrink)

On the traditional view, moral distress arises only in cases where an individual believes she knows the morally right thing to do but fails to perform that action due to various constraints. We seek to motivate a broader understanding of moral distress. We begin by presenting six types of distress that fall outside the bounds of the traditional definition and explaining why they should be recognized as forms of moral distress. We then propose and defend a new and more expansive (...) definition of moral distress and examine how it can enable the development of a taxonomy of moral distress. (shrink)

Very few moral philosophers have written on climate change.1 This is puzzling, for several reasons. First, many politicians and policy makers claim that climate change is not only the most serious environmental problem currently facing the world, but also one of the most important international problems per se.2 Second, many of those working in other disciplines describe climate change as fundamentally an ethical issue.3.

What might a theory of mental imagery look like, and how might one begin formulating such a theory? These are the central questions addressed in the present paper. The first section outlines the general research direction taken here and provides an overview of the empirical foundations of our theory of image representation and processing. Four issues are considered in succession, and the relevant results of experiments are presented and discussed. The second section begins with a discussion of the proper form (...) for a cognitive theory, and the distinction between a theory and a model is developed. Following this, the present theory and computer simulation model are introduced. This theory specifies the nature of the internal representations (data structures) and the processes that operate on them when one generates, inspects, or transforms mental images. In the third, concluding, section we consider three very different kinds of objections to the present research program, one hinging on the possibility of experimental artifacts in the data, and the others turning on metatheoretical commitments about the form of a cognitive theory. Finally, we discuss how one ought best to evaluate theories and models of the sort developed here. (shrink)

The concept of representation has become almost inextricably bound to the concept of symbol systems. the concepts is nowhere more prevalent than in descriptions of "internal representations." These representations are thought to occur in an internal symbol system that allows the brain to store and use information. In this paper we explore a different approach to understanding psychological processes, one that retains a commitment to representations and computations but that is not based on the idea that information must be stored (...) and manipulated in symbol systems. In particular, we suggest that the notion of a symbol system as currently understood construes psychological processes in terms of a specific type of computational system, in which a control function "reads," "interprets," and manipulates discrete entities called "symbols." We argue that other types of computational systems may provide a more appropriate characterization of psychological processes. One implication of our argument is the need to consider the constraints placed on computational theories in psychology by the nature of the computing device itself, the human brain. Perhaps surprisingly, this implication leads us to the conclusion that a "functionalist" conception of psychological processes (discussed below) does not entail that physiology is irrelevant to psychology, as has been maintained by prominent adherents of the symbol-systems approach. (shrink)

This paper argues that extortion is a clear threat in intergenerational relations, and that the threat is manifest in some existing proposals in climate policy and latent in some background tendencies in mainstream moral and political philosophy. The paper also claims that although some central aspects of the concern about extortion might be pursued in terms of the entitlements of future generations, this approach is likely to be incomplete. In particular, intergenerational extortion raises issues about the appropriate limits to the (...) sway of central values such as welfare and distributive justice. We should be wary of ways in which such values invite us to buy off, or perhaps to join, an intergenerational climate Mafia. (shrink)

ABSTRACT In Debating Climate Ethics, David Weisbach and I offer contrasting views of the importance of ethics and justice for climate policy. I argue that ethics is central. Weisbach advocates for climate policy based purely on narrow forms of self-interest. For this symposium, I summarize the major themes, and extend my basic argument. I claim that ethics gets the problem right, whereas dismissing ethics risks getting the problem dangerously wrong, and perpetuating profound injustices. One consequence is that we should reject (...) the alleged “feasibility constraint” of short-term, economic self-interest. (shrink)

In this paper I review some theoretical exchanges and empiricalresults from recent work on human behavior and cognition in thehope of indicating some productive avenues for critical engagement.I focus particular attention on methodological debates between Evolutionary Psychologists and behavioral ecologists. I argue for a broader and more encompassing approach to the evolutionarily based study of human behavior and cognition than either of these two rivals present.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appear monthly in Crisis and The Wanderer. In it, he discusses how the current oppressive actions directed against those who oppose or dissent on religious grounds to various aspects of the sexual revolution—such as the agenda of the homosexualist movement—are in line with the oppressive actions directed against those who opposed blatant sexual immorality by politically powerful figures at earlier historical times, such (...) as King Henry VIII in England. Effectively, sexual immorality has at times in history paved the way for political tyranny and reshaped nations. (shrink)

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appear monthly in Crisis and The Wanderer. It discusses the solid social science research that shows the harms to children raised in same-sex households. He says that in spite of this the child protective system, which seems to regard such things as spanking and free-range parenting as child abuse/neglect apparently does not view the harms of same-sex parenting to be worthy of investigating. (...) Krason suggests that this is because of the ideological biases that characterize the CPS. (shrink)

In 2001, 178 of the world's nations reached agreement on a treaty to combat global climate change brought on by anthropogenic emissions of greenhouse gases. Despite the notable omission of the United States, representatives of the participants, and many newspapers around the world, expressed elation. Margot Wallström, the environment commissioner of the European Union, went so far as to declare, “Now we can go home and look our children in the eye and be proud of what we have done.”In this (...) article, I argue for two theses. First, the rhetoric and euphoria surrounding the 2001 deal is misplaced. This is not, as is often said, because the Kyoto agreement is too demanding but rather because it is much too weak. In particular, the Kyoto agreement does little to protect future generations. On the contrary, (at best) it seems to be a prudent wait-and-see policy for the present generation, narrowly defined. Hence, even those countries who have endorsed the Kyoto agreement should be wary of looking their children in the eye, and none should relish facing their children's children.Second, the failure of the Kyoto agreement can be explained in terms of the underlying structure of the problem. Climate change involves the intersection of a complex set of intergenerational and intragenerational collective action problems. This structure, and in particular its intergenerational aspect, has not been adequately appreciated. Yet until it is, we are doomed to an ineffectual environmental policy. (shrink)

Wagering contingent on a previous decision, or post-decision wagering, has recently been proposed to measure conscious awareness. Whilst intuitively appealing, it remains unclear whether economic context interacts with subjective confidence and how such interactions might impact on the measurement of awareness. Here we propose a signal detection model which predicts that advantageous wagers placed on the identity of preceding stimuli are affected by loss aversion, despite stimulus visibility remaining constant. This pattern of predicted results was evident in a psychophysical task (...) where we independently manipulated perceptual and economic factors. Changes in wagering behaviour induced by changes in wager size were largely driven by changes in criterion, consistent with the model. However, for near-threshold stimuli, a reduction in wagering efficiency was also evident, consistent with an apparent but potentially illusory decrease in awareness of the stimulus. These findings challenge an assertion that post-decision wagering provides a direct index of subjective awareness. (shrink)

A critical study of two recent books in climate ethics by Dale Jamieson (Reason in a Dark Time, Oxford 2014), and Darrel Moellendorf (The Moral and Political Challenges of Climate Change, Cambridge 2014).

In the last twenty years, the study of translation has emerged as a discipline in its own right.1 Scholars in various fields have turned their attention to the linguistic, philosophical, and ideological issues involved in the ‘carrying over’ of ideas from one language into another. This new discipline has a natural affinity with Latin philology, since the Romans may be regarded as pioneers in the art of translation in the West. At present, however, we have only begun to study what (...) they really thought about translation and how they went about doing it. In the present paper,31 will re-examine a valuable but under-appreciated witness: Aulus Gellius, author of the Attic NightsSome of Gellius′ brief essays contain translations from Greek, and a few of them were prepared specifically as exercises in the ars interpretandi.By studying them, we learn how the questions associated with translation were addressed by a Roman litterateur of the Antonine period. (shrink)

SCSS President Stephen M. Krason wrote this letter in response to a review about a book he edited and contributed to in the SCSS’s Catholic Social Thought Book Series, The Crisis of Religious Liberty: Reflections from Law, History, and Catholic Social Thought. The review, which appeared in The Journal of Church and State, was mostly favorable to the book but made erroneous assertions and a false and unmerited conclusion about the sources Krason used in his Afterword in the book. (...) Krason also sent the letter to the editor of the Journal, but they apparently don’t run letters and did not make an exception with this one. Krason also sent a copy of this letter to the other contributors to the book and includes it here out of a sense of the need to have a public record of a response to a published book review that, of course, was publicly disseminated. (shrink)

Collegiality among nurses is necessary for the accomplishment of the tasks of care, for safety and quality improvement and for professional self‐regulation. Nurses, especially in hospitals, are more likely to work in groups than other professionals, yet those relationships have not been well explored. Bullying, intimidation and fear are frequently identified, while respectful disagreements are rarely described. In this paper, a single story by a nurse about her conversational conflict with another nurse is given a close reading. I use the (...) ‘triadic line’ of William Carlos Williams to format an extended excerpt of interview text, in order to make visible the rhythms and organization of spoken language. Mills' concept of a ‘vocabulary of motives’ is used to examine the rhetorical strategies deployed by each nurse. Finally, I analyze the narrative structure of the story, highlighting the ways that moral certainty and uncertainty function to involve the reader in the story, and the complex role of virtue in nursing discourse. (shrink)

This was one of SCSS president Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appeared in Crisismagazine.com and The Wanderer. At a time when there is increased discussion about the need for criminal justice reform, he points to several areas that must be addressed: overcriminalization, vagueness of laws, the decline of mens rea, too much readiness on the part of American police to arrest, excessive incarceration, and prosecutorial abuse.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appear monthly in Crisis and The Wanderer. In it, he summarizes his conclusions about the conformity of current American conservatism with Catholic social teaching—as put forth in the papal social encyclicals—on the subject of economics and social welfare policy from his 2017 book, Catholicism and American Political Ideologies. His analysis is based on the 2012 Republican party platform, which was held to be (...) a particularly conservative document—and thus a good measure of current conservative thinking on public policy questions. He concludes that American conservative thinking about economics and social welfare policy conforms reasonably well—certainly not perfectly—with Catholic social teaching. (shrink)

This article was one of SCSS President Stephen M. Krason’s online “Neither Left nor Right, but Catholic” columns. It appeared on April 1, 2012. There is a link to Krason’s monthly column at the SCSS website. Since August 2012, his column also appears at Crisismagazine.com. This article considers new, serious threats to free speech in the contemporary Western world.

This article was one of SCSS President Stephen M. Krason’s online “Neither Left nor Right, but Catholic” columns. It appeared on May 1, 2012. There is a link to Krason’s monthly column at the SCSS website. Since August 2012, his column also appears at Crisismagazine.com. This article considers weaknesses in present-day conservatism, and how embracing certain principles of Catholic social teaching could rectify those weaknesses.

This was one of SCSS president and Franciscan University of Steubenville professor Stephen M. Krason’s “Neither Left Nor Right, but Catholic” columns that appeared initially in Crisismagazine.com on May 1, 2013. It argues why the U.S. criminal justice system is in a state of crisis. It argues that what seem to be ideologically-oriented critiques of the problems of the system actually have their basis in traditional Christian thinking.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appeared during 2014 in Crisismagazine.com and The Wanderer and at his blog site. He argues that, despite the criticism of President Obama’s seemingly excessive exercise of executive power to further an ideologically leftist secularist agenda, the strong and maybe unprecedented use of presidential power after him may be the most certain way to try to restore weakened American constitutional principles and traditional liberties (...) and to begin to reverse our serious cultural decay. (shrink)

This was one of SCSS President, Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appear monthly at his blog site and in Crisismagazine.com and The Wanderer. This column tells families and others proposing the “Benedict Option”—i.e., trying to separate as much from the secular culture as possible and trying to build up small Catholic subcultures where their children can be effectively reared in the Faith and family integrity preserved—to be attentive of the threat posed by the (...) current child protective system and the need to seek to reform it. (shrink)

This was one of SCSS President, Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appear monthly at his blog site and in Crisismagazine.com and The Wanderer. This column speaks about what might be called a new expression of literalism and fundamentalism, especially among liberal Catholics and some in Church leadership, to take certain Scriptural passages and Church teachings and apply them to current situations and public questions without regard to the context of the situations or full (...) attention to nuances or even to the facts present—to in a certain sense absolutize the contingent. Sometimes this is done to promote certain policy agendas and without even considering the full statement of the Church’s teaching, as it is expressed in the social encyclicals and other documents. (shrink)

This article is one of SCSS President Stephen M. Krason’s “Neither Left nor Right but Catholic” online columns. It looks at the “Occupy Wall Street” protests, and aims primarily at drawing a comparison between them and the protests of the 1960s. It also assesses them in light of Catholic social teaching.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appeared during 2015 in Crisismagazine.com and The Wanderer and at his blog site. He makes an assessment, in light of Catholic social teaching, of the race issue in America today. He argues that the typical commentary about it ignores obvious realities, is often driven by ideology and the opportunism of self-appointed racial spokesmen, and ignores serious, deep-seated problems in minority communities with tragic (...) consequences. (shrink)

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns that appeared during 2014 in Crisismagazine.com and The Wanderer and at his blog site. It discusses how Catholic social teaching does not mandate particular public policies and must not be confused with a point of the teaching itself. It emphasizes that there can typically be many different policy approaches that can be used to make sure that moral demands are met.

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns in The Wanderer in 2021. In it, he writes that the Democratic party has increasingly embraced the agenda of the left, been tolerant of violence by radical organizations, been willing to compromise the principle of the rule of law, and shown increasing intolerance of opposing perspectives and a tendency to political repression. This article is reprinted with permission.

We focus on a particular class of computably enumerable degrees, the array noncomputable degrees defined by Downey, Jockusch, and Stob, to answer questions related to lattice embeddings and definability in the partial ordering of c. e. degrees under Turing reducibility. We demonstrate that the latticeM5 cannot be embedded into the c. e. degrees below every array noncomputable degree, or even below every nonlow array noncomputable degree. As Downey and Shore have proved that M5 can be embedded below every nonlow2 degree, (...) our result is the best possible in terms of array noncomputable degrees and jump classes. Further, this result shows that the array noncomputable degrees are definably different from the nonlow2 degrees. We note also that there are embeddings of M5 in which all five degrees are array noncomputable, and in which the bottom degree is the computable degree 0 but the other four are array noncomputable. (shrink)

This essay introduces and defends a new analysis of prudential value. According to this analysis, what it is for something to be good for you is for that thing to contribute to the appeal or desirability of being in your position. I argue that this proposal fits well with our ways of talking about prudential value and well-being; enables promising analyses of the related concepts of luck, selfishness, self-sacrifice, and paternalism; preserves the relationship between prudential value and the attitudes of (...) concern, love, pity, and envy; and satisfies various other desiderata. I also highlight two ways in which the analysis is informative and can lead to progress in our substantive theorizing about the good life. (shrink)

There are a number of competing hypotheses about human evolution. For example, Homo habilis and Homo erectus could have existed together, or one could have evolved from the other, and paleontological evidence may allow us to decide between these two hypotheses (see, e.g., Spoor et al., 2007). For most who work on the biology of human behavior, there is no question that human behavior is in some large part a product of evolution. But, there are competing hypotheses in this area (...) as well. Some claim that human behavior is produced by a collection of psychological mechanisms, for the most part, and that these mechanisms are adaptations that arose in the Pleistocene Epoch (e.g., Tooby & Cosmides, 1992; Buss, 2007). The claim is important and testable (although, more difficult to test than the above mentioned hypotheses about origins); but importantly, it is only one among many hypotheses about the evolutionary origins of human behavior. While I think that there may be components of our behavior that are best explained by appealing to processes or mechanisms that arose in the Pleistocene, I think that human behavior is a result of evolutionary processes both much older and more recent than the Pleistocene. I also maintain that much of human behavior, and the mechanisms underlying it, could still be subject to evolutionary.. (shrink)

I pose problems for the views that human nature should be the object of study in the social and behavioral sciences and that a concept of human nature is needed to guide research in these sciences. I proceed by outlining three research programs in the social sciences, each of which confronts aspects of human variation. Next, I present Elizabeth Cashdan and Grant Ramsey’s related characterizations of human nature. I go on to argue that the research methodologies they each draw on (...) are more productive resources for social scientists than their competing characterizations of human nature. (shrink)

Recently in the pages of The Classical Quarterly Mathias Hanses convincingly demonstrated the existence of a fourth occurrence of the programmatic adjective λεπτός in Aratus, Phaen. 783–7. This new example occurs in the form of a diagonal acrostic alongside the known ‘gamma-acrostic’ and the occurrence of the same form of the adjective in line 784. Jerzy Danielewicz has now proposed yet a fifth instance of λεπτή in the form of an acronym spread over two lines and meant to be read (...) anticlockwise. (shrink)

This chapter contains sections titled: Coda: Getting Something Back Notes.

Stephen M. Krason presented this talk at the “Stand Up for Religious Freedom” rally in Buffalo, New York on June 8, 2012. It was one of many that were held around the U.S. that day, to show opposition to the attempt by the Obama administration’s Department of Health and Human Services to mandate that religious entities provide free contraceptives and sterilization procedures in their health insurance programs.

Climate change is a global problem that is predominantly an intergenerational conflict, and which takes place in a setting where our ethical impulses are weak. This "perfect moral storm" poses a profound challenge to humanity. This book explains how the "perfect storm" metaphor makes sense of our current malaise, and why a better ethics can help see our way out.

The philosophical literature on well-being and the good life contains very little explicit discussion of what makes for a better or worse death. The purpose of this essay is to highlight some commonly held views about the good death and investigate whether these views are recognized by the leading theories of well-being. While the most widely discussed theories do have implications about what constitutes a good death, they seem unable to fully accommodate these popular good death views. I offer two (...) partial explanations for why these views have been neglected in discussions of well-being and make two corresponding recommendations for future work in the philosophy of well-being. (shrink)

This was one of SCSS President Stephen M. Krason’s “Neither Left nor Right, but Catholic” columns in The Wanderer in 2021. In it, he says that in spite of the left’s irresponsible claims about “systemic racism” in America, motivated by their ideological objectives, they pay little attention to the real problems in the Black community such as illegitimacy, family breakdown, and fatherlessness. This article is reprinted with permission.